Several selective autophagy pathways, such as mitophagy, xenophagy, lipophagy and aggrephagy, have been investigated using zebrafish and still need to be studied further, while other selective autophagy pathways, such as pexophagy or reticulophagy, could also benefit from the use of the zebrafish model. In this review, we shed light on how zebrafish contributed to our understanding of these selective autophagy processes by providing the in vivo platform to study them at the organismal level and highlighted the versatility of zebrafish model in the selective autophagy field. Abbreviations AD Alzheimer disease; ALS amyotrophic lateral sclerosis; Atg autophagy-related; CMA chaperone-mediated autophagy; CQ chloroquine; HsAMBRA1 human AMBRA1; KD knockdown; KO knockout; LD lipid droplet; MMA methylmalonic acidemia; PD Parkinson disease; Tg transgenic.Objectives To demonstrate that 1) models based on small numbers of tests can be statistically developed to identify neuropsychological impairment in a general adult neuropsychology clinic and 2) those models show strong predictive validity on replication in a slightly different sample. Method Latent Class Analyses (LCA) were used to determine neuropsychological classification in 231 patients referred to general adult neuropsychology services. A clinical rating scale was also used to approximate clinical decision-making. Regression models were constructed in a training sample (n?=?127) drawn from an adult neuropsychology clinic using test scores from seven different a priori test battery combinations to predict group membership or clinical rating. The utility of the seven models was assessed in a testing sample (n?=?104) from another independent adult neuropsychology clinic. Results The LCA yielded a two class solution characterized by impaired versus non-impaired performance on neuropsychological tests. A seven test battery provided the best balance of accuracy and length in predicting LCA group with a sensitivity of 84.4% and a specificity of 90%. Sensitivity and specificity were slightly attenuated using the clinical rating scale as the criterion, but the seven test battery still provided good accuracy (AUC=.906). Conclusions Test protocols based on only five to eight test scores can accurately identify most patients with clinical impairment in a diverse adult neuropsychology clinic. Development of short protocols with adequate sensitivity and specificity will become increasingly important to address long waiting lists in light of the COVID pandemic against the general backdrop of increasing demand for neuropsychological services.Eosinophilic esophagitis (EoE) is a relatively recently identified but now frequently encountered antigen/immune-mediated disease which places significant burden on patients and the healthcare system. With its growing prevalence and recognition by healthcare providers in multiple disciplines, substantial progress has been made regarding the diagnostic criteria, clinical evaluation, tools for disease assessment, and immune pathways related to pathogenesis. Current treatment goals focus on the amelioration of inflammation and prevention of remodeling consequences using proton pump inhibitors, swallowed topical steroids, elimination diets, and esophageal dilation. Ongoing research holds promise for more efficacious and targeted therapies as well as a personalized approach to the care of patients with EoE.The objective of this study was to compare the pick-up rate of pathogenic BRCA variants in those with a high-grade serous ovarian carcinoma (HGSOC) undergoing oncology-led testing with the traditional genetics family history-based testing model. With novel therapies, BRCA status can affect treatment. Welsh oncologists are now testing all women with HGSOC at diagnosis rather than referring to genetics, where family history is required for testing. The records of 332 women who underwent testing via oncology were analysed. The outcome measures were; percentage of women with a pathogenic BRCA variant and the difference in identification of pathogenic BRCA variants between the oncology-led and traditional genetics testing models. Of the 332 women, 25 women (7.5%) tested positive for a pathogenic BRCA variant. https://www.selleckchem.com/products/peg400.html This was slightly lower than the detection rate of 9.8% for patients tested via the genetics service over the same period. Testing through genetics, using family history criteria would have identified only 19hods. With the advent of targeted treatments such as olaparib, women with a pathogenic BRCA variant can access different life extending treatment options. With comparable pick-up rates to traditional family history based scoring systems, oncologists can now arrange BRCA gene testing directly. What are the implications of these findings for clinical practice and/or further research? Our study shows universal genetic testing of those with high-grade serious ovarian carcinoma by oncologists allows more women to access life extending treatment in a shorter timeframe compared to the traditional testing model used by clinical genetics services. We hope that other centres, both in the UK and beyond, will adopt this approach.Preeclampsia (PE), the primary pathology of which is endothelial cell (EC) dysfunction, has long-lasting effects such as cardiovascular disease. Therefore, it was decided to investigate the maternal serum concentrations of EC-specific molecule-1 in patients with early-onset preeclampsia (E-PE). This study was conducted on 33 pregnant women with E-PE and 35 healthy pregnant women matched for gestational age. EC-specific molecule-1 level was measured using a commercially available enzyme-linked immunosorbent assay kit. The mean EC-specific molecule-1 concentrations were not significantly different between the groups (651.7?±?632.2?pg/mL vs. 425.9?±?263.0?pg/mL, p=.056). Among women with E-PE, the median EC-specific molecule-1 concentration did not differ significantly by disease severity (p=.115). EC-specific molecule-1 is not involved in the pathogenesis of E-PE. However, some studies in the literature report that EC-specific molecule-1 concentrations increased during the diagnosis of PE. Therefore, well-designed studies with a large sample are needed in cases of E-PE.